The Science

Three clinical studies (2 acute, 1 chronic)
were conducted at the Technion – Institute of Technology, Sleep Laboratory, Rambam Medical Center by:
Giora Pillar, MD, PhD, is a professor at the Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. He received his medical and scientific degrees from the Technion, and thereafter completed a fellowship at the Sleep Medicine, Endocrinology, and Circadian Rhythm Department, Brigham & Women’s Hospital and Harvard Medical School, Boston, USA.  He is certified by the American Board of Sleep Medicine and has 20 years of experience in diagnosing and treating patients with sleep disorders.
First clinical study: Double-blind placebo and active (caffeine) controlled study to examine the effects of the herbal nutritional supplement beverage "WakeUp" on vigilance and function after lunch.
Higher performance on all tests was seen at 30 minutes for WakeUp!® compared to caffeine and placebo (P<0.05 for all), [MWS1] however, after 120 minutes WakeUp!® performance remained high compared to placebo, but caffeine performance decreased significantly on all tests compared to WakeUp!® (all p<0.05) There were no differences in heart rate or blood pressure for WakeUp!® consumption.
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Second Clinical Study: Longitudinal open label prospective study to assess the efficacy and tolerance of daily usage of the wake promoting beverage "Wake up".
Performance on vigilance, concentration and Digit Symbol Substitution Test (DSST)  all improved 1 hour after consumption of WakeUp compared to before use on Days 1 and 30 (all p<0.05). No tolerance over time was observed.
 On Day 31, performance on vigilance, concentration, work performance, immediate Word Recall Test (iWRT) parameters all decreased one hour following lunch (p<0.01), providing additional proof-of-concept data DSST significantly improved over the course of 30 days with a plateau instead of a reduction on day 31, suggesting that consistent ingestion of WakeUp may improve brain function (processing speed) over time
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Third clinical study: "Open label prospective study to assess the efficacy of the wake promoting beverage "WakeUp" on vigilance and function of healthy volunteers in the morning and in the evening"
Open label study assessing the efficacy of one bottle of WakeUp!® in the morning (8:30 am) and one in the late afternoon/evening (6:30pm) of the same day before and 30 minutes after drink. Testing done before and 30 minutes after consumption. Outcome measures included Objective iWRT, DSST Standard subjective scale for vigilance, focus and work performance. Read Study
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“Composition comprising natural extracts“
United States Patent No. 13/917,129
"Composition comprising natural extracts"-Granted
European Patent Application No. 13196952.9
"Composition comprising natural extracts" - Granted
Japanese Patent Application No. 2013-257384
"Composition comprising natural extracts"-Granted
Israeli Patent Application No. 226913
"Composition comprising natural extracts"
US Trademark No. 86138675 in Classes 50 and 32 in the name of InnoBev Ltd.

Approved Claims

Suggested Structure-Function Claims for use only in USA

According to the clinically studies done with WakeUp!® formula,
the following suggested structure-function claims may be used in USA only as follow:

1. Helps managing post lunch dip
2. Supports work performance
3. Supports focus
4. Supports wakefulness
5. Supports alertness
6. Supports vigilance